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The purpose is to know the anxiety level in epileptic patients and compare this level with the anxiety presented in a group of healthy patients and another of migraine sufferers. To identify the characteristics of the anxiety in each group and compare some of their neurobiological characteristic. METHODS: It was performed a study using Hamilton test to specify anxiety on 100 patients with epileptic diagnosis; this study was compared with a similar group of patients with migraine. Anxiety was classified according to the results obtained from Hamilton test as: anxiety 0 or 1 anxiety or mild anxiety ; both of them are considered as normal.
Screening for substance abuse problems and dual diagnosis Substance abuse. Reliable and consumer-friendly instruments may facilitate screening. The modified version of the 4-item CAGE, which includes screening for substance abuse, is one such instrument Table 2 ; .38-41 Before administering the CAGE questions, the health care provider may want to ask the patient a general question, such as "Do you perceive any problem in the way you use alcohol or drugs?" This could then be followed by gentle, unhurried questioning to allow time for meaningful answers ; with the CAGE items and albuterol.
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As for PTSD, one of the most valuable goals of personalized medicine for people with schizophrenia is the identification of objective markers for early diagnosis and intervention, given that these factors are crucial to a good prognosis. We have postulated that the mechanism underlying the symptoms of schizophrenia is a disorganization of neural integration, and that this disorganization is reflected in neuromarker disturbances in cognition and emotion processing. Indeed, given that neural synchrony plays a key role in the integration of discrete perceptions and cognition [23], abnormal synchronization in schizophrenia could result in the misattribution between internal and external stimuli. In line with the identification of an early and trait-like neuromarker, we have found that abnormal neural synchrony is present at the very first episode of psychosis and continues into chronic schizophrenia Figure 6 ; [24]. In the high frequency 40 Hz ; -EEG band, people with schizophrenia show a reduction in peak synchrony relative to matched controls. The above examples show that objective neuromarkers of brain-related conditions can be identified and may form the basis of a personalized medicine for these conditions. An integrated framework that brings genomics and.
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STEPHEN GOUGH, MD, FRCP, Division of Medical Sciences, University of Birmingham and Birmingham Heartlands Hospital, Birmingham; ROBERT PEVELER, MA, DPhil, FRCPsych, Community Clinical Sciences Division, University of Southampton, Southampton, UK Correspondence: Dr S. C. L.Gough, Birmingham Heartlands Hospital, Bordesley Green East, Birmingham B9 5SS, UK. Tel: 0 ; 121 4243593; fax: 0 ; 121 4240593; e-mail: s.c.gough bham.ac s.c.gough and zyban.
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