Learn more about community partnerships in the website We support a wide range of health and education initiatives in the communities where we operate. Donations are made centrally and by GSK sites to support local charities and good causes. Below are just a few examples of the many community partnerships we supported in our four main regions during 2004. Europe Barretstown in Ireland and L'Envol in France are residential camps where seriously ill children can have fun and develop their self confidence. GSK gave 250, 000 $458, 000 ; and 100, 000 $183, 000 ; respectively, to support the camps in 2004. Employees also give their time to Barretstown and L'Envol with over 40 GSK employees participating in 2004. Three new European programmes were launched, each receiving a grant of 300, 000 $549, 000 ; over three years. These were: Change in Advance, a disease prevention programme that promotes healthy eating and exercise, aimed at Slovakian children living on urban housing estates a programme in Spain that provides healthcare for homeless and abandoned children Multi Coloured Lives, an interactive education programme to help children with disabilities integrate into Russian society International GSK contributed 100, 000 $183, 000 ; to the Integrated Management of Childhood Illnesses IMCI ; initiative in Ethiopia, in partnership with WHO and UNICEF. IMCI aims to reduce childhood deaths from preventable and treatable conditions such as pneumonia, diarrhoea, malaria, measles, and malnutrition. It helps families to improve the health of their children through better nutrition and healthcare. In Vietnam GSK is supporting the `500 Ethnic Midwives' initiative with $335, 000 183, 000 ; in funding. The funding is being used to build a training centre where 500 women from Vietnam's ethnic minority groups will become trained midwives. People from ethnic communities often live in poor rural areas where there is little access to healthcare services. The new midwives will play an important role helping to improve mother and child health in their home towns. UK GSK supports over 70 charitable organisations in the UK. In 2004 this included over 500, 000 $915, 000 ; to support medical research undertaken by the charities Breakthrough Breast Cancer, Cystic Fibrosis Trust, DEBRA, Ehlers-Danlos Support Group and the Motor Neurone Disease Association.
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Swiss, age 65 Function at Novartis AG Alexandre F. Jetzer has served as a Director since 1996. He is a Non-Executive Director. Activities in governing or supervisory bodies Alexandre F. Jetzer is also a member of the Board of Directors of Clariden Bank, Zurich, Switzerland, of the Supervisory Board of Compagnie Financire Michelin, Granges-Paccot FR ; , Switzerland, and of the Board of the Lucerne Festival Foundation, Lucerne, Switzerland. Professional background Alexandre F. Jetzer graduated with Masters of law and economics from the University of Neuchtel, Switzerland and is a licensed attorney. After serving as General Secretary of the Swiss Federation of Commerce and Industry Vorort ; from 1967 on, Alexandre F. Jetzer joined Sandoz in 1980. In 1981 he was appointed Member of the Sandoz Group Executive Committee in the capacity of Chief Financial Officer CFO ; and, as of 1990, as Head of Management Resources and International Coordination. From 1995 to 1996, he was Chairman and Chief Executive Officer of Sandoz Pharmaceuticals Corporation in East Hanover, New Jersey US ; and he additionally served as President and CEO of Sandoz Corporation in New York NY ; . After the merger which created Novartis in 1996 until 1999, he was appointed as a member of the Executive Committee of Novartis and Head of International Coordination, Legal & Taxes. Permanent management or consultancy engagements Alexandre F. Jetzer has a consultancy agreement with Novartis International AG Government Relations Support ; . In addition he is a member of the International Advisory Panel IAP ; on Biotechnology Strategy of the Prime Minister of Malaysia and a member of the Development Committee of the Neuroscience Center of the University of Zurich, Switzerland.
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REFERENCES 1. Blazquez, E., E. Montoya, and C. L. Quijada. Relationship between insulin concentrations in plasma and pancreas of foetal and weanling rats. J. Endocrinol. 48: 553561, 1970. Buts, J. P., N. D. Keyser, S. Marande, A. S. Maernoudt, E. M. Sokal, J. Rahier, and D. Hermans. Expression of insulin receptors and of 60-kDa receptor substrate in rat mature and immature enterocytes. Am. J. Physiol. 273 Gastrointest. Liver Physiol. 36 ; : G217G226, 1997. 3. Dumont, Y., L. Larose, G. Poirier, and J. Morisset. Delayed weaning and denial of solid food nibbling upon pancreatic acinar cell responsiveness to urecholin in neonatal rats. Digestion 18: 93102, 1978. Giorgi, D., J. P. Bernard, R. Lapointe, and J. C. Dagorn. Regulation of amylase messenger RNA concentration in rat pancreas by food content. EMBO J. 3: 15211524, 1984. Girard, J., P. Ferre, J. P. Pegorier, and P. H. Duee. Adapta tions of glucose and fatty acid metabolism during perinatal period and suckling-weaning transition. Physiol. Rev. 72: 507 562, Gonnella, P. A., K. Siminoski, R. A. Murphy, and M. R. Neutra. Transepithelial transport of epidermal growth factor by absorptive cells in suckling rat ileum. J. Clin. Invest. 80: 2232, 1987. Hall, W. G. Weaning and growth of artificially reared rats. Science 190: 13131315, 1970. Henning, S. J. Postnatal development: coordination of feeding, digestion, and metabolism. Am. J. Physiol. 241 Gastrointest. Liver Physiol. 4 ; : G199G214, 1981 and isoptin.
Health Canada received 10 238 new domestic reports of suspected adverse reactions ARs ; in 2004. The ARs were reported for the most part by health professionals pharmacists, physicians, nurses, dentists, coroners and others ; , either directly to Health Canada or indirectly through another source Table 1 ; . A further analysis of the total number of reports by reporter type originator ; is outlined in Table 2. Of the AR reports received, 7000 68.4% ; were classified as serious. A serious AR is defined in the Food and Drugs Act and Regulations as "a noxious and unintended response to a drug which occurs at any dose and requires inpatient hospitalization or prolongation of existing hospitalization, causes congenital malformation, results in persistent or significant disability or incapacity, is life-threatening or results in death." There has been a steady increase in the reporting of ARs in Canada over the past 6 years, with 11.2% more reports in 2004 than in 2003 Fig. 1 ; . Health Canada would like to thank all who have contributed to the program and encourages the continued support of post-marketing surveillance through AR reporting. ARs may be reported by using the toll-free telephone 866 234-2345 ; and fax 866 678-6789 ; lines, because autism.
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Force by ~25 % in papillary muscles of healthy rats and by ~40 % in papillary muscles of diabetic rats. Reasons of the discrepancies between the studies are not clear, but the differences in experimental design could contribute to this. The concentration of extracellular Ca2 + , a crucial factor for cardiac contractility, was different in these studies and it was previously shown that the inotropic effect of insulin is dependent on extracellular Ca2 + Schmidt and Koch 2002 ; . At Ca2 + concentration of 2.5 mmol l insulin did not influence the contraction force, at lower Ca2 + concentrations a positive inotropic effect of insulin was found and at higher Ca2 + concentrations a negative inotropic effect of insulin occurred Schmidt and Koch 2002 ; . These experiments, however, were performed in whole rat hearts. In papillary muscles the relationship between insulin and Ca2 + concentration seems to be different. The site of origin of papillary muscles can also be of importance. No inotropic effect of insulin was found in left ventricle papillary muscles Ren et al. 1999 ; , whereas we found a negative inotropic effect of insulin in right ventricle papillary muscles. Previously, both electrophysiological and contractile differences were.
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This petition, submitted on behalf of Sepracor Inc, requests that FDA take the following actions: confirm that the approval of the NDA for LunestaTM eszopicolone ; tablets became effective on April 4, 2005; confirm that that five-year exclusivity for Lunesta commenced on the date of effective approval, April 4, 2005; and confirm that the patentterm extension for Lunesta should be calculated based on the effective date of approval. Author: Venable, LLP Date: 12 30 2005 Page s ; : 31 AAC Doc.# 009-3457.
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