1, 2 ; the duration of action of tiotropium is 24 hours or more, which makes it suitable for once-daily dosing.
This system has a key function in hepatic oxidative drug metabolism including the degradation of coumarin derivatives , and common metabolic pathways together with the limited metabolic capacity of the involved cyp isoenzymes are the major reason why so many drug-drug interactions occur, for instance, asthma.
These new endoscopic therapies for gerd can provide an alternative to medical or surgical treatments.
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Tiotropium 18 µ g, once daily ; was added via a dry-powder inhaler device.
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One study Figure 3 ; reported on development of congestive heart failure or cardiogenic shock in patients with diabetes according to whether patients were hyperglycaemic or not defined as blood glucose of greater than 10 mmol L ; . The rate was 3% in both those with hyperglycaemia and without hyperglycaemia Table.
Discontinued. All participants will be maintained on inhaled fluticasone 500 mcg bid; Flovent Diskus, GlaxoSmithKline Canada, Mississauga, ON ; . Short-acting 2adrenoceptor agonists e.g. salbutamol ; and or anticholinergic ipratropium ; will be allowed as rescue medications. Long-acting anticholinergic medication i.e. tiotropium ; will also be permitted, if clinically indicated as judged by the participants' attending physician. Longacting 2-adrenoceptor agonists, however, will be prohibited and tizanidine.
Skills Gaps Table 13 Jordan: Skills Gap by Service Categories illustrates the gaps between Table 9 Jordan: Experienced Skills by Service Category on page 120 and Table 11 Jordan: Skills Demand by Service Category on page 123. Figure 18 Jordan: Skills Gap by Year of Experience, just below Table 13 summarizes the skills gaps by years of experience.
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Your pharmacist has additional information about tiotropium inhalation written for health professionals that you may read and urso.
November 9-13, 13th World Congress ofSocial Psychiatry, The Indian Association for Social Psychiatry and the World Association for Social Psychiatry, New Delhi. Contact: Prof. Vijoy K. Varma, Chairman, Organizing Committee, Department of Psychiatry, Postgraduate Institute of Medical Education & Re.
RESOURCE PERSONS FOR TRAINING OF FIELDWORK TEAM Mr Ananga Yamyollia, Ghana Health Service Ms Edith Andrews, EDM NPO WHO Country Office Mr Charles Allotey, Catholic Drug Centre HAI Ghana Mrs Martha Gyansa-Lutterodt, Ghana National Drugs Programme REGIONAL FIELDWORK DATA TEAMS Ashanti Region Mr Dominic Dobbin Mr Dominic Otchere Miss Naana Frempong Ms Abena Aseidu Offei Upper-East Region Mr Akodam Karbo Mrs Diana Awuni Dr William Gudu Mr Razak Abdulai DATA ENTRY AND PROCESSING Mrs Priscilla Eshun Ms Lydia Afoko REPORT WRITING Ms Edith Andrews Mr Ananga Yamyollia Mr Charles Allotey Mr Martin Auton Mrs Martha Gyansa-Lutterodt Western Region Mr S. T. Asamoah Dr Robert A. Sagoe Steven Essuman Henry Hammond Greater Accra Region Dr Tom Thompson Ms Lydia Afoko Rev Sr Veronica Amponsah Isaac Annan and ursodiol.
L Slack-Smith1, L Wood1, K France1, K Hunt1, S Eades2, T Eades1 2. School of Dentistry, University of WA, WA 3. The Sax Institute, NSW Introduction: Despite extensive research and activity discouraging smoking in Australia, prevalence in pregnant Aboriginal women remains high, with many detrimental effects on the mother and child. This study, with researchers working closely with the community, was an important opportunity to determine the issues for pregnant Aboriginal women with regard smoking. The broad aim was to explore the issues and context, perceptions and attitudes regarding smoking among pregnant Aboriginal women, health workers and other women. Methods: This project was suggested by Aboriginal women and was developed with a community reference group and utilized Aboriginal staff wherever possible. It was a qualitative study using focus groups and in-depth interviews to explore issues regarding smoking in pregnant Aboriginal women. Those interviewed included pregnant women, those of childbearing age and Aboriginal Health Workers AHWs ; . Outcomes: There were many outcomes in this study including capacity building, learning for all involved and a detailed understanding of the context of smoking. This talk will highlight 1 ; The importance of research approach; 2 ; The context of smoking in the women's lives; and 3 ; The role of AHWs. Conclusion and Recommendations: This study clearly demonstrates the importance of understanding the context before developing interventions for smoking in some groups. Sometimes progress in smoking cessation requires taking a step back to understand before intervening. The authors would especially like to thank Healthway for funding this research.
References 1. Global Initiative for Chronic Obstructive Lung Disease. Global Strategy for the Diagnosis, Management and Prevention of COPD; 2005. URL: : goldcopd 2. The Burden of COPD in New Zealand. Published by the Asthma and Respiratory Foundation of New Zealand, October 2003. 3. Marsh S et al. Complete reference ranges for pulmonary function tests from a single New Zealand population. NZMJ 2006 27-Oct2006 - Vol 119 No 1244 4. Barr RG et al. Inhaled tiotropium for stable chronic obstructive pulmonary disease Review ; . The Cochrane Database of Systematic Reviews 2005, Issue 2 and valproic.
Departments of Physiology and 2 Pharmacology Lagos State University College of Medicine, P. M. B. 21266, Ikeja. Lagos, Nigeria.
Nitude was not associated with any gain in endurance capacity in patients who developed contractile fatigue of the quadriceps Figure 2 ; . The implication of this study is that the presence of leg fatigue modulates the exercise-response to bronchodilation. This concept is further supported by a pooled analysis of the two large, multicentre, randomized clinical trials evaluating the efficacy of tiotropium during cycling exercise in patients with COPD.6, 8, 18 In this study, the magnitude of the improvement in the endurance time to constant work-rate cycling exercise was smaller in patients whose main exercise limiting symptom was leg fatigue compared to those reporting dyspnea as their primary limitation to exercise.18 An important clinical message arises from those studies. The occurrence of leg fatigue will prevent patients with COPD from obtaining full advantage of bronchodilation. In these patients, treatment of the peripheral muscles in combination with pharmacological interventions should be incorporated into the management plan. 3. Susceptibility to muscle fatigue Before addressing how to treat the peripheral muscle, a brief overview of the mechanisms underling fatigue susceptibility in COPD is warranted. Muscle weakness, a common finding in COPD19-21, is an obvious contributor to muscle fatigue. In a weak muscle, the imbalance between the force necessary to maintain a given contraction and the maximum force will 172 Med clin exp vol 29, n 0 3, juin 2006 and valacyclovir!
Periodic BP for persons aged 21 yr. 2If sexually active at present or in the past: q 3 yr. If sexual history is unreliable, begin Pap test at age 18 yr. If sexually active. 4Serologic testing, documented vaccination history, and routine vaccination against rubella preferably with MMR ; are equally acceptable alternatives. 5Consider screening with full DSM-IV criteria for attention deficit disorder, inattentive or hyperactive types, in children with significant overall academic or behavioral difficulty including academic failure and or learning difficulty, especially in reading, math or handwriting. 6 Persons using alcohol and or drugs. Physical and behavioral indicators: liver disease, pancreatitis, hypertension, gastritis, esophagitis, hematological disorders, poor nutritional status, cardiac arrhythmias, alcoholic myopathy, ketoacidosis, neurological disorders: smell of alcohol on breath, mood swings, memory lapses or losses, difficulty concentrating, blackouts, inappropriateness, irritability or agitation, depression, slurry speech, staggering gait, bizarre behavior, suicidal indicators, sexual dysfunction, interpersonal conflicts, domestic violence, child abuse and neglect, automobile accidents or citation arrests, scholastic or behavior problems, secretiveness or vagueness about personal or medical history. 7Persons with a weight 10% below ideal body weight, parotid gland hypertrophy or erosion of tooth enamel. Females with a chemical dependency. 8In women who are at increased risk, diagnostic evaluation should include an assessment of history of sexual and physical violence, interpersonal difficulties, prescription drug utilization, medical and reproductive history. 9Recent divorce, separation, unemployment, depression, alcohol or other drug abuse, serious medical illness, living alone, homelessness, or recent bereavement, for example, nasal spray.
Tiotropium was administered via the handihaler ® and formoterol was administered via the aerolizer ® both devices are dry powder inhalers and ativan.
Statistics Australian Institute of Health and Welfare : aihw.gov.au Other Support Services Brisbane Prostate Cancer Support Group Us Too Australia Us Too Prostate Support Group Atherton ; Us Too Prostate Support Group Hervey Bay ; Cairns Prostate Cancer Support Group Prostate Awareness Group Townsville ; The Association of Prostate Cancer Support Groups 07 ; 3371 9155 03 ; 9347 2522 07 ; 4091 2255 07 ; 4152 3796 07 ; 4056 1461 07 ; 4723 2693 02 ; 9337 3371, for example, tiotropium.
Members of the Scream Theater at Rutgers But consenting sex doesn't "just happen." University NJ ; perform during orientation for Consenting sex requires sober, verbal communication incoming students a program called "Sex Under without intimidation or threats. Many states' laws Pressure." The performance begins with a brief recognize that when someone is drunk they are unable introduction by the facilitator who defines to give consent. Additionally, being drunk is never an sexual violence and discuses why this issue is excuse for raping someone. important. Then six peer educators perform a 20-minute skit that demonstrates different Excerpt from Acquaintance Rape: What Everyone scenarios of dating pressure, one of which ends Should Know, a pamphlet by the American College in a rape. Alcohol is usually presented in the Health Association.20 scenes both as a normal part of socializing among college students and as a possible factor in sexual violence. The level of which alcohol is presented as a factor in the skits depends upon the student actors, and is most often used as part of the context of sexual violence, not as a motivator. The student actors feel that it is important to address the reality of alcohol in their lives and to learn how to draw the line between consent and nonconsent when alcohol is involved. 21 Students are challenged to consider their beliefs about rape, how alcohol impacts those beliefs and how the characters might have changed their behavior to alter the situation. Scream Theatre is funded by a state grant and performs both on the Rutgers campus, and for other colleges and high schools throughout their area. The program has received very positive attention and have been struggling to keep up with the demand made by local high schools. The large demand for programs like Scream Theatre in high schools is promising, as one program director believes that alcohol education must happen before students get to college.22 No outcome data are available and bextra.
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Rather as a disease with at least partial reversibility of airflow limitation. Several classes of bronchodilators are available, in particular b2-adrenergic receptor agonists, both short- or fast-acting SABA ; and long-acting LABA the antimuscarinic anticholinergics, also both short-acting SAAC ; and long-acting LAAC and oral slow-release theophylline. In the present review the role of inhaled anticholinergic bronchodilators, and in particular that of the newly developed LAAC tiotropium bromide Spiriva H, Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim, Germany ; , in the.
2003 ; , pp. 399404. 31. D Tashkin and S Kesten, "Long-term Treatment Benefits with Giotropium in COPD Patients With and Without Shortterm Bronchodilator Responses", Chest, 123 2003 ; , pp. 1, 4411, 449. R Casaburi, D A Mahler, P W Jones, A Wanner, P G San, R L ZuWallack, S S Menjoge, C W Serby, and T Witek Jr, "A Long-term Evaluation of Once-daily Inhaled T9otropium in Chronic Obstructive Pulmonary Disease", Eur. Resp. J., 19 2002 ; , pp. 217224. 33. M Cazzola, C F Donner, and M G Matera, "Long-acting 2-agonists and Theophylline in Stable Chronic Obstructive Pulmonary Disease", Thorax, 54 1999 ; , pp. 730736. 34. D Murciano, M Aubier, Y Lecocguic, and R Pariente, "Effects of Theophylline on Diaphragmatic Strength and Fatigue in Patients with Chronic Obstructive Pulmonary Disease", N. Engl. J. Med., 311 1984 ; , pp. 349353. 35. F L Eldridge, D E Millhorn, T G Waldrop, and J P Kiley, "Mechanism of Respiratory Effects of Methylxanthines", Respir. Physiol., 53 1983 ; , pp. 239261. 36. D Murciano, M H Auclair, R Pariente, and M Aubier, "A Randomized Controlled Trial of Theophylline in Patients with Severe Chronic Obstructive Pulmonary Disease", N. Engl. J. Med., 320 1989 ; , pp. 1, 5211, 525. P J Barnes, "Therapy of Chronic Obstructive Pulmonary Disease", Pharmacol.Ther., 97 2003 ; , pp. 8794. 38. A D D'Urzo, M C De Salvo, A Ramirez-Rivera, J Almeida, L Sichletidis, G Rapatz, and J Kottakis, "In Patients with COPD, Treatment with a Combination of Formoterol and Ipratropium is More Effective Than a Combination of Salbutamol and Ipratropium: A 3-week, Randomized, Double-blind, Within-patient, Multicenter Study", Chest, 119 2001 ; , pp. 1, 3471, 356. R L ZuWallack, D A Mahler, D Reilly, N Church, A Emmett, K Rickard, and K Knobil, "Salmeterol Plus Theophylline Combination Therapy in the Treatment of COPD", ibid., pp. 1, 6611, 670. M Cazzola and M G Matera, "Long-acting Bronchodilators are the First Choice Option for the Treatment of Stable COPD", ibid., in press. 41. R C Tennant, E M Erin, P J Barnes, and T T Hansel, "Long-acting 2-adrenoceptor Agonists or Tiot5opium Bromide for Patients with COPD: Is Combination Therapy Justified?", Curr. Opin. Pharmacol., 3 2003 ; , pp. 270276. 42. R A Pauwels, C G Lfdahl, L A Laitinen, J P Schouten, D S Postma, N B Pride, and S V Ohlsson, "Long-term Treatment with Inhaled Budesonide in Persons with Mild Chronic Obstructive Pulmonary Disease Who Continue Smoking: European Respiratory Society Study on Chronic Obstructive Pulmonary Disease", N. Engl. J. Med., 340 1999 ; , pp. 1, 9481, 953. J Vestbo, T Sorensen, P Lange, A Brix, P Torre, and K Viskum, "Long-term Effect of Inhaled Budesonide in Mild and Moderate Chronic Obstructive Pulmonary Disease: A Randomized Controlled Trial", Lancet, 353 1999 ; , pp. 1, 8191, 823. P van Der Valk , E Monninkhof, J van Der Palen, G Zielhuis, and C van Herwaarden, "Effect of Discontinuation of Inhaled Corticosteroids in Patients with Chronic Obstructive Pulmonary Disease: The COPE Study", Am. J. Respir. Crit. Care Med., 166 2002 ; , pp. 1, 3581, 363. J B Soriano, J Vestbo, N B Pride, V Kiri, C Maden, and W C Maier, "Survival in COPD Patients after Regular Use of Fluticasone Propionate and Salmeterol in General Practice", Eur. Respir. J., 20 2002 ; , pp. 819825. 46. M Cazzola, G Di Lorenzo, F Di Perna, F Calderaro, R Testi, and S Centanni, "Additive Effects of Salmeterol and Fluticasone or Theophylline in COPD", Chest, 118 2000 ; , pp. 1, 5761, 581. L Pang and A J Knox, "Synergistic Inhibition by 2-agonists and Corticosteroids on Tumor Necrosis Factor-a-induced Interleukin-8 Release from Cultured Human Airway Smooth-muscle Cells", Am. J. Respir. Cell. Mol. Biol., 23 2000 ; , pp. 7985. 48. R Pauwels, "Inhaled Glucocorticosteroids and Chronic Obstructive Pulmonary Disease: How Full is the Glass?", ibid., 165 2002 ; , pp. 1, 5791, 580. R B Dowling, M Johnson, P J Cole, and R Wilson, "Effect of Fluticasone Propionate and Salmeterol on Pseudomonas Aeruginosa Infection of the Respiratory Mucosa In Vitro", Eur. Respir. J., 14 1999 ; , pp. 363369. 50. L Pang and A J Knox, "Regulation of TNF--induced Eotaxin Release from Cultured Human Airway Smooth Muscle Cells by 2-agonists and Corticosteroids", FASEB J., 15 2001 ; , pp. 261269. 51. J N Baraniuk, M Ali, D Brody, J Maniscalco, E Gaumond, T Fitzgerald, G Wong, A Yuta, J C Mak, P J Barnes, R Bascom, and T Troost, "Glucocorticosteroids Induce 2-adrenergic Receptor Function in Human Nasal Mucosa", Am. J. Respir. Crit. Care Med., 155 1997 ; , pp. 704710. 52. J C Mak, M Nishikawa, H Shirasaki, K Miyayasu, and P J Barnes, "Protective Effects of Glucocorticoid on Downregulation of Pulmonary 2-adrenergic Receptors In Vivo", J. Clin. Invest., 96 1995 ; , pp. 99106. 53. O Eickelberg, M Roth, R Lrx, V Bruce, J Rudiger, M Johnson, and L H Block, "Ligand-independent Activation of the Glucocorticoid Receptor by 2-adrenergic Receptor Agonists in Primary Human Lung Fibroblasts and Vascular Smooth Muscle Cells", J. Biol. Chem., 274 1999 ; , pp. 1, 0051, 010. European Committee for Proprietary Medicinal Products CPMP ; , press release, 23 January 2003 and cialis.
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Numerous methods have been utilized to acquire compounds for drug discovery, including isolation from plants and other natural sources, synthetic chemistry, combinatorial chemistry and molecular modelling8, 9 . Despite the recent interest in molecular modelling, combinatorial chemistry and other synthetic chemistry techniques by pharmaceutical companies and funding organizations, natural products and particularly medicinal plants, remain an important source of new drugs, new drug leads and new chemical entities NCEs ; . According to Newman et al.10, 61% of the 877 small-molecule NCEs introduced as drugs worldwide during 19812002 was inspired by natural products. These include: natural products 6% ; , natural products derivatives 27% ; , synthetic compounds with natural products-derived pharmacophore 5% ; and synthetic compounds designed from natural products natural products mimic, 23% ; 4, 10 . Ten examples of successful drugs derived from plants Figure 1 ; are briefly described here. Arteether 1 ; is a potent anti-malarial drug and is derived from artemisinin, a sesquiterpene lactone isolated from Artemisia annua L. Asteraceae ; , a plant used in traditional Chinese medicine11, 12. Galanthamine 2 ; is a natural product discovered through an ethnobotanical lead and first isolated from Galanthus woronowii Losinsk. Amaryllidaceae ; in Russia. Galanthamine is approved for the treatment of Alzheimer's disease, slowing the process of neurological degeneration by inhibiting acetylcholine esterase as well as binding to and modulating the nicotinic acetylcholine receptor 13, 14 . Tjotropium 3 ; has been released recently in the US for treatment of chronic obstructive pulmonary disease15, 16 . Tio6ropium is an inhaled anticholinergic bronchodilator, based on ipratropium, a derivative of atropine, isolated from Atropa belladonna L. Solanaceae ; and other members of the Solanaceae family17 . Morphine6-glucuronide 4 ; is a metabolite of morphine from Papaver somniferum L. Papaveraceae ; , reported as an alternative pain medication with fewer side effects than morphine18 . Exatecan 5 ; is an analogue of camptothecin isolated from Camptotheca acuminata Decne. Nyssaceae ; and being developed as an anticancer agent 4, 19 . Vinflunine 6 ; is a modification of vinblastine from Catharanthus roseus G. Don Apocynaceae ; for use as an anticancer agent with improved efficacy20 . Compounds 46 ; all are in phase III.
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This system is associated with significant reduction in the production of the primary metabolite and additional improvement in the tolerability profile of the drug and danazol and tiotropium, because 5iotropium inhalers.
199 157: 2413-244 swales, j in the oxford textbook of medicine.
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Bioequivalence was established by meeting the fda criterion of confidence intervals falling between 80% and 125% when comparing levels of each drug in patients dosed with the coformulation compared with the individual compounds and darvon.
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To be quite accurate and recall of other medications less accurate. To assess recall accuracy for medications, investigators have commonly used medical records or prescription records as the "gold standard." Neither medical records nor pharmacy records are subject to recall bias, but pharmacy records are commonly considered more complete for assessment of medication use 2023 ; . We used pharmacy records from a health maintenance organization and two retail pharmacy chains to evaluate the accuracy of self-reported medication exposures for three 6-month, 2-year, and 8-year ; time windows. The following drug classes were evaluated: anti.
Your Secure Horizons Prescription Advantages Plan offers a discount on Non-Covered Prescription Drugs. Here's how to obtain your discount: 1. For a 30-day supply, present both your prescription and your Secure Horizons Prescription Advantages Plan ID card at a contracting pharmacy and request your discount up to 15% ; , OR 2. For a 90-day supply through the Prescription Solutions Mail-Service Pharmacy, contact Prescription Solutions at 1-800-562-6223 to determine your prescription cost. Your cost will be our discounted rate. Payment may be made by credit card or by mailing a check included with your order. Please note, there may be minor fluctuations in the price quoted and the price billed. You will be responsible for the actual price at the time the product is dispensed.
| Tiotropium reviewPatients should always check with a pharmacist or the physician before taking any type of new medication.
6.6. PHARMACOTHERAPY .18 6.6.1. Indications for Pharmacotherapy.18 6.6.2. Goals of Therapy.19 6.6.3. Types of anti- obesity drugs.19 6.6.3.1. Drugs acting on the gastrointestinal system.19 6.6.3.2. Drugs acting on the central nervous system .20 6.6.4. Other Drugs that induce weight loss .20 6.6.5. Agents not appropriate for the treatment of obesity .20 6.6.6. Antiobesity agents under development .21 6.6.6.1. Leptin .21 6.6.6.2. Neuropeptide-Y.21 6.6.6.3. Glucagon and glucagon- like peptide-1 .21 6.6.6.4. Beta-3 adrenergic receptor agonists .21 6.6.7. Contra-indications to the use of anti-obesity drugs .21 7. Surgery for Weight Loss .22 7.1. Criteria for Surgical Therapy .23 7.2. Surgical Techniques in Current Use .23 7.3. Complications of Surgical Therapy .23 8. PEDIATRIC AND ADOLESCENT OBESITY.24 8.1. Evaluation of Obesity.24 8.2. Management of Childhood Obesity: .25 8.3. Prevention of Obesity.26 9. Appendices.27 10. References.31, for example, flovent.
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Lieberman IH, eds. Atlas of Minimal Access Spine Surgery. 2nd ed. St Louis, MO: Quality Medical Publishing, Inc; 2004; chap 23. Funding Source: None. * Roseville: 916.784.4000 ; Picetti GD III, * Mathews DK, Bueff HU and tizanidine.
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Home : : health-and-fitness diseases gastritis treatments by sean glenn article word count: 537 comments 0 ; while many cases of gastritis are caused by the pylori bacterium, which attacks the stomach lining, a lot of gastritis patients are the victim of something that actually belongs in the system: stomach acid.
In addition, check your blood pressure regularly, seek medical treatment if your blood pressure is high, and stop smoking to further help reduce your risk for a heart attack or stroke.
It was the school that demanded that he be placed on the drugs.
Opinion. This means that there may be uncertainty for policyholders in many instances because latency claims can vary in many ways and it begs the question of "just how valuable are losses occurring wordings". In many instances the imagined benefit will not exist. In any event, trying to rely upon a policy issued many years earlier presents a number of problems in itself, not least being tracing the policy and the adequacy of the limit of indemnity. As recently as the 1970s, many policy limits were as low as 250, 000. For insurers, long tail liabilities present some significant problems. Apart from coping with the cost of legacy claims, insurers need to be able to price the business they are writing today but will be the future source of claims. In order to price accurately, insurers must be able to assess the likely frequency and severity of claims. This is virtually impossible for claims with a long latency. In 1971 when the UK government was in the throes of introducing compulsory insurance requirements for employers' liability, one of the issues was the financial limit on the minimum level of insurance required. It decided that 2m was an appropriate amount, based upon the fact that claims for even 1m were difficult to imagine and that 2m simply could not happen. In 2005, we are looking at settlements of 15m or more for very serious injury cases. These cases take time to settle; a similar accident happening today may not be settled until, say, 2012, so what will be the equivalent value at that time? Over a long period, it is impossible to predict wage inflation, social inflation, inflation in the cost of care as well as increases in court awards. It is also impossible to predict the advances in medical science that will occur over such a period. This may act to the benefit or detriment of the insurer in terms of finding a cure or carrying out a more accurate diagnosis. Any medical development that prolongs the life expectancy of a claimant will increase the cost of the claim. Equally, we have to consider what changes are made to the law or how the law is interpreted.
Here, six trends will be detailed that need to be confronted, exploited and conquered as genomic science goes beyond drug discovery and controlled clinical trials into the real world of practicing physicians and healthcare consumers, formerly referred to as patients. Personalized medicine introduces a daunting foray into the complexities, for example, side effects.
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Address for reprint requests and other correspondence: M. R. Ruggieri, Sr., Director of Urologic Research, Temple Univ. School of Medicine, 3400 N. Broad St., 715 OMS, Philadelphia, PA 19140-5104 E-mail: rugg1 msn ; . R874.
2002; 4: 120– abstract drug-induced hepatotoxicity is an important cause of hepatocellular injury.
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