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We have previously shown that hLigI is phosphorylated in a cell cycle-dependent manner. After dephosphorylation in early G1, the enzyme is progressively phosphorylated on Ser66 during S-phase and a hyperphosphorylated form of hLigI, with a lower electrophoretic mobility, is detectable in M-phase Rossi et al., 1999 ; . In this work we studied whether the phosphorylation status of hLigI could be modulated not only during the cell cycle but also in response to DNA damage. To this, exponentially growing HeLa cells were treated with VP-16, a drug known to induce replicationmediated DSBs. DSBs are, in fact, generated when replication forks encounter topo II-DNA cleavable complexes trapped by the drug Kaufmann, 1998 ; . After a 3-h treatment with 100 M VP-16, cells were allowed to recover for 3 or 24 normal medium before being analyzed by Western blotting to assess the phosphorylation status of hLigI. Because VP-16 is a well known apoptotic agent Negri et al., 1993; Kaufmann, 1998 ; , in parallel we determined the occurrence of apoptosis by following different morphological parameters such as nuclear condensation and fragmentation. A very low level of apoptosis 3.5 0.1% ; was detectable at the end of the 3-h treatment with VP-16. The apoptotic index increased during the recovery period, reaching 10 0.6 or 49 1.9% after 3 and 24 h of recovery, respectively. After a 24-h recovery most of the apoptotic cells were floating in the medium. Extracts prepared from untreated cells, from adherent cells collected after 3 or 24 recovery and from floating cells collected at 24 h, were analyzed by Western blotting with a rabbit polyclonal antiserum directed against.
ABSTRACT. The game theoretical approach to R&D cooperation does not investigate the role of trust in the initiation and success of R&D cooperation: it either assumes that firms are non-opportunists or that the R&D cooperation is supported by an incentive mechanism that eliminates opportunism. In contrast, the present paper focuses on these issues by introducing incomplete information and two types of firms: opportunist and non-opportunist. Defining trust as the belief of each firm that its potential collaborator will respect the contract, it identifies the trust conditions under which firms initiate R&D alliances and contribute to their success. The higher the spillovers, the higher the level of trust required to initiate R&D cooperation for non-opportunists, while the inverse holds for opportunists. KEY WORDS. Non-cooperative game, R&D cooperation, Trust and opportunism. JEL CLASSIFICATION CODE: C720 Non-cooperative games; L130 Market structure, firm strategy and performance; D320 Management of technology, innovation and R&D.
Cally different isolates isolates 1002 to 1005 ; and very good one for isolate 1001 were established, if adequate kinetic parameter values, i.e. k2 and Dm values, were applied for particular isolates. Table 2 contains data showing differences between isolates 1001 and 1003 with reference to their colony growth and antibiotic synthesis kinetics, as well as to the agreement of theoretical with experimental data. The differences between two isolates are very pronounced with reference to both growth kinetics and product formation parameters, whereas the agreement of theoretical with experimental data was very good for growth kinetics data of both isolates and antibiotic formation kinetics of the isolate 1003. The correlation for antibiotic produced by colonies of the isolate 1001 was found to be slightly less adequate. It follows that presented data suggest the applied mathematical model represented by eqs. 1, 1a, 4, can be accepted, as already was previously concluded, on the basis of same and additional data.1 Figs.1 and 2 refer to cultures of S. rimosus R6500 and demonstrate cultivation process kinetics of this strain. Excellent agreement of theoretical with experimental data for applied mathematical model composed of mathematical eqs. 2, 3, 79 and 11 has been found, disregarding whether data refer to shaken flask cultures or to the batch culture in laboratory bioreactor. Since a trial to apply the same mathematical model for explaining experimental data referring to cultures of S. rimosus MV9R-1 was unsuccessful, it was necessary to modify the mentioned mathematical model. Experimental data and data of preliminary computer simulations suggested the use of mathematical model defined by eqs. 2, 3, 1821. Computer simulation confirmed this hypothesis, as can be well seen in Figs. 3 and 4. Based on a rough insight into experimental data it was expected for the strain S. rimosus MV9R-2 to show some similarity with respect to S. rimosus R6500 behaviour. Therefore, an applicability of the same mathematical model in explaining the behaviour of both strains was expected. Data in Figs. 5 and 6 completely confirmed the expectation. Similarity between two strains with respect to their process kinetics is quite evident. However, data suggest the strain MV9R-2 appears to be inferior in comparison with S. rimosus R6500 strain. An excellent way to demonstrate behaviour differences between investigated strains was by comparing their theoretical specific growth, substrate uptake and product formation rates, as shown in Fig. 7 a, b, c. Differences are better high-lighted if kinetics of substrate uptake and product formation are considered.
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Positive titer was 100 for Ab to thyroglobulin and 400 for Ab to thyroid microsomes. Antinuclear Ab, anti-smooth muscle Ab, and gastric anti-parietal cell Ab were determined by indirect immunofluorescence on sections of mouse stomach and kidney using slides purchased from Kallestad Laboratories, Austin, Tex. A titer of 40 was considered positive. Antiendothelial Ab was detected by immunofluorescence using fresh-frozen monkey heart sectioned at 4 fim on a cryostat and fixed in cold 4C ; acetone for 30 seconds. Sera were tested at a 1: and a 1: 40 dilution and incubated for 30 minutes at room temperature. A goat anti-human fluorescein-labeled anti-IgG was then applied for 30 minutes. A positive control serum was included in all studies. Rheumatoid factor was determined by fluorescence immunoassay FIAX, M.A. Whittaker Bioproducts, Inc., Walkerville, Md. ; . Anticardiolipin Ab was determined by enzyme-linked immunosorbent assay ELISA ; .22 Immunocomplexes were detected by the use of a qualitative electrophoretic assay.23 Antineuronal Ab was detected by an ELISA procedure using a saline extract of normal human hippocampus collected within 6 hours of death ; as the antigen. The protein concentration was 11 mg dl, and the extract was coated onto 96-well, flat-bottomed microtiter plates. After blocking unbound sites with bovine serum albumin, patient and control sera were added to coated and uncoated wells, after which IgG antibody binding was detected by adding goat anti-human IgG conjugated with alkaline phosphatase. Color development was by -nitrophenylphosphate, and a reaction was considered positive when the optical density of the color in the well containing antigen was 2.5 times that of the uncoated well. One-way analysis of variance ANOVA ; and a contrast analysis were used to analyze Mini-Mental State and eulexin.
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Although anticonvulsant activity was evident at the micromolar concentrations associated with functional NMDA antagonism and or blockade of multiple subtypes of HVA Ca2 + channel, other mechanisms may contribute to the anticonvulsant activities of at least some of the compounds tested. Most notably, although adenosine and CM had similar eects on I O functions, they elicited opposite actions on PPF in that CM markedly depressed the facilitation of test responses to the extent that paired-pulse depression PPD ; emerged. The ability of CM to elicit PPD appears unlikely to reect its ability to reduce excitatory transmitter release see above ; because this would have the eect, as in the case of adenosine, to enhance PPF Dunwiddie & Haas, 1985; Debanne et al., 1996 ; . Rather, the depressant eect of CM on PPF observed at short conditioning-testing intervals may reect an augmentation of an underlying feed-forward ; inhibitory conductance activated by the conditioning stimulus References.
4. Availability of ongoing mental health care Suitable care may be unavailable due to specific eligibility criteria or gatekeeping functions for example, mental health care may be only available to those with a diagnosed mental health disorder or restricted to those with a `severe' mental disorder. However Silburn and Zubrick 1995 ; reviewed 182 consecutive deliberate self-harm presentations at accident and emergency departments in Perth, and noted that only 57% of youth aged 14-19 were found to have a psychiatric diagnosis. Furthermore services may focus on a specific model of care and may not be flexible enough to meet the needs of a range of clients. 5. Psychotherapy is frequently an important component of ongoing care The client frequently requires a psychotherapeutic as well as a medical and or case management response. Recent research indicates that psychotherapy is an effective intervention in a range of psychopathological conditions including depression e.g., Jarrett, 1995 ; . Furthermore positive gains are associated with a number of psychotherapeutic approaches, and not just limited to one particular theoretical model Cotton, 1998; Docherty & Streeter, 1993 ; . While Jobes 1995a ; has called for more outcome research evaluating psychotherapy with suicidal clients, the research which has been done has yielded some encouraging findings. Linehan's work with borderline clients who repeatedly self-harm is one example of a program where evaluation has indicated a positive outcome. Her intervention with this complex client group did show a reduction in suicidal behaviour for those who stayed with the program Linehan, Armstrong, Suarez, Allmon, & Heard, 1991 ; . Despite the growing evidence of its effectiveness, there are many clinical settings where psychotherapeutic intervention is not readily available. 6. Facilitating client engagement with ongoing therapy and or follow-up Non-adherence with treatment recommendations is common across the full range of health and mental health services. It is not clear whether the rate of nonadherence is any different in clients presenting with self-harm, but the possible consequences of non-adherence may be of particular concern. As mentioned above, the need for further research into, and training in, good referral processes is an important issue here. In the context of suicide risk, there have been a few studies investigating nonadherence among adolescent suicide attempters. In general, parental attitudes and characteristics are an important predictor of adolescents' attendance for treatment Spirito, Brown, Overholser, & Fritz, 1989 ; . In a recent study, family dysfunction, mother characteristics and father-adolescent relationship variables were all linked to non-attendance at parent guidance family therapy, while mother characteristics were related to poor follow-through for adolescent individual therapy and medication take-up King, Hovey, Brand and raloxifene.
Attention deficit hyperactivity disorder ADHD ; is one of the most common mental disorders in children. Approximately 70 to 80 percent of children and adults respond to medications for the treatment of this disorder.
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Rahim, S.A., Ismail, N.D., Bashir, W.A. 1986 ; Spectrophotometric determination of aniline in aqueous solution by azodye formation with diazotized p-nitroaniline. Mikrochim. Acta, III 5-6 ; : 417-423. Rajeswari, C.V., Naidu, A.V., Naidu, P.R. 1984 ; . Simple colorimetric method for the determination of carbofuran and bendiocarb in formulations. Curr. Sci., 53: 800-801. Raju, J., Shivahare, P., Gupta, V.K. 1992 ; . Rapid and sensitive screening method for the determination of carbaryl and propoxur using p-nitroaniline. Int. J. Environ. Anal. Chem., 49 3 ; : 111-115. Rusling, J.F., Scheer, B.J., Haque, I.U. 1984 ; . Voltammetric oxidation of vinblastine and related compounds. Anal. Chim. Acta, 158 1 ; : 23-32. Sapunova, L.A., Gaevskii, A.V., Maslova, G.A., Grodnitskaya, E.I. 1982 ; . Determination of vinblastine and leurosine in the above ground parts of catharanthus roseus Donn. Khim. Farm. Zh., 16 6 ; : 708-715. Sastry, C.S.P., Rao, S.G., Sastry, B.S. 1992 ; . Spectrophotometric determination of butylated hydroxyanisole in oils. J. Food Sci. Technol., 29: 101-102. Sethi, V.S., Burton, S.S., Jackson, D.V. 1980 ; . Sensitive radio-immunoassay for vincristine and vinblastine. Cancer chemother. Pharmacol., 4 3 ; : 183-187. Tabacco, A., Bardelli, F., Meiattini, F., Tarli, P. 1980 ; . A simplified Kinetic method for the determination of uric acid in serum with a single Fe III ; -2, 4, 6-triyridyl-1, 3, reagent. Clin. Chim. Acta, 104: 405-407. Temizer, A. 1986 ; . Electroanalytical determination of vinca alkaloids used in cancer chemotherapy. Talanta, 33 10 ; : 791794. United States Pharmacopoeia XXIV. 2000 ; . USP convention Inc. Rockville. MD 20852, p. 1744-1746. Van Tellingen, O., Beijnen, J.H., Baurain, R., Tenbokkel Huinink, W.W., Vanderwonde, H.R., Nooyen, W.J. 1991 ; . Highperformance liquid chromatographic determination of vinblastine, 4-0-deacetylvinblastine and the potential metabolite 4-0-deacetylvinblastine-3-oic acid in biological fluids. J. chromatogr., 553 1 ; : 47-53. Volkov, S.K. 1996 ; . Determination of vinblastine and vincristine by HPLC. Khim. Farm. Zh., 30 3 ; : 58-62. Volkov, S.K., Grodmitskaya, E.I. 1994 ; . Application of HPLC to the determination of vinblastine in cantharus roseus. J. chromatogr. B. Biomed. Appl., 660 2 ; : 405-408. Wei, Y., Pei, D. 1997 ; . Continuous spectrophotometric assay of peptide deformylase. Anal. Biochem., 250: 29-34, because ibuprofen.
Publications in Academic Journals & Contributions to Edited Works D. Bexheti, E. Anderson, A.J. Hutt & M. Hanna-Brown 2006 ; . Evaluation of Multidimensional Capillary Electrophoretic Methodologies for Determination of Amino Bisphosphonate Pharmaceuticals. Journal of Chromatography A, 1130, 137-144. A.J.Hutt 2006 ; . Drug chirality and its pharmacological consequences. In: Introduction to the Principles of Drug Design and Action, H.J. Smith Ed ; , 4th edition; CRC Press Taylor & Francis ; Boca Raton & London ; , pp 117183. R. Cizmrikov, J. Valentov, A.J. Hutt & S. Sedkov 2005 ; . Bloktory -adrenergickch receptorov skupina chirlnych lieciv stereoselektivna syntza -bloktorov. Czech and Slovak Pharmacy, 54, 201-206. R. Cizmrikov, J. Valentov & A.J. Hutt 2004 ; . Bloktory adrenergickch receptorov skupina chirlnych lieciv: enantioseparcie v skupine -bloktorov. Czech and Slovak Pharmacy, 53, 9-17. B.K. Patel, M. Hanna-Brown, M.R. Hadley & A.J. Hutt 2004 ; . Enantiomeric resolution of 2-arylpropionic acid non-steroidal antiinflammatory drugs by capillary electrophoresis: methods and applications. Electrophoresis, 25, 2625-2656. T. Bassindale, D.A. Cowan, S. Dale, A.J. Hutt, A.R. Leeds, M.J. Wheeler & A.T. Kicman 2004 ; . Effects of oral administration of androstenedione on plasma androgens in young women using hormonal contraception. Journal of Clinical Endocrinology & Metabolism , 89, 6030-6038. J. Valentov & A.J. Hutt 2004 ; . Chirlni zmna "chiral switch": cist enantiomery lciv msto racemickch sms. Czech and Slovak Pharmacy, 53, 285-293. B.K. Patel & A.J. Hutt 2004 ; . Stereoselectivity in drug action and disposition: an overview. In: Chirality in Drug Design and Development; Eds: I.K.Reddy & R.Mehvar; Marcel Dekker New York ; , pp 139-190. M.R. Hadley, M.W. Harrison & A.J. Hutt 2003 ; . Use of chiral zwitterionic surfactants for enantiomeric resolutions by capillary electrophoresis. Electrophoresis, 24, 2508-2513. B.K. Patel, S.H.D. Jackson, C.G. Swift & A.J. Hutt 2003 ; . Disposition of flurbiprofen in man: influence of stereochemistry and age. Xenobiotica, 33, 1043-1057 and vaseretic.
Local people in the Highlands are being urged to nominate their healthcare heroes to reward and celebrate the valuable contribution they make to people's lives and NHS Scotland. The Scottish Health Awards 2007, which will bestow well deserved acclaim on NHS workers who have helped to transform lives, cure illnesses, advance services or improve people's healthcare experience, were launched by Cabinet Secretary, Nicola Sturgeon in June. She said: "People working in the NHS make a difference every day, and they don't always get the recognition they deserve. The Daily Record Scottish Health Awards is a chance for the whole of the NHS and patients to celebrate the hard work and dedication of some special members of staff." You can nominate online by visiting scottishhealthawards or email v.smith dailyrecord for an entry form or call the enquiry line on 01413091480. All nominations must be received no later than Friday 10th September 2007. Page 5.
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Slowing down the progression of kidney disease, especially in diabetics. While a cough may occur in about 15%20% of patients who are taking an ACE inhibitor, cough is rare with the ARBs. Combinations of an ACE inhibitor with a diuretic Capozide, Lotensin HCT, Prinzide, Vaseretic, or Zestoretic ; or an ARB with a diuretic Atacand HCT, Avalide, Benicar HCT, Diovan HCT, or Hyzaar ; have been shown to increase the number of people who respond to goal blood pressure levels of below 140 90 mm Hg from about 40%50% when only one drug is given to about 75%80%. These medications may also be considered for initial treatment. Calcium channel blockers have been in use for more than 15 years. They act by preventing calcium from entering blood vessel walls or heart muscle. There are several different types of these agents; some will mostly block the effects of calcium on blood vessels. Others will also affect the heart rate. Drugs such as DynaCirc CR, Norvasc, Plendil, Procardia XL, or Sular are effective in dilating blood vessels, whereas Calan SR, Cardizem CD, Dynacin, or Isoptin SR may dilate blood vessels but also slow down the heart rate. Calcium channel blockers are also available in combination with ACE inhibitors. Examples include Lexxel, Lotrel, and Tarka. Other medications. There are many other effective drugs available, such as alpha beta-blockers--Coreg or Normodyne Trandate. The alpha-blockers--Cardura, Hytrin, or Minipress may be useful in combination with other medications and will often help to relieve the symptoms of an enlarged prostate in men. Apresoline and Loniten dilate blood vessels directly. Drugs that are no longer and myambutol and oretic.
Chromatograph the System suitability solution, and record the peak responses as directed for Procedure: the column efficiency is not less than 8000 theoretical plates, and the tailing factor is not more than 1.8. Chromatograph the Standard solution, and record the peak responses as directed for Procedure: the relative standard deviation for replicate.
In finance, a general assumption is that price movements are random. Bachelier 1900 ; was the first to formulate stock price movements with a stochastic process. More precisely, he modelled stock price movements with a Brownian motion B t, ; . The movements of a Brownian motion are random and its state is normally distributed at any given time. The increments of a Brownian motion are independently distributed. Finally, there is a version of Brownian motion for which the mapping t B t, ; is continuous for almost all 1 . An extensive period of empirical and theoretical research on stock prices followed the work of Bachelier, but mostly in the latter half of the 1900s. Muth 1961 ; developed a general theory of rational expectations which was complemented by Lucas 1972, 1976 ; . The theory of rational expectations states that people form expectations as rationally as they can on the basis of available information. Samuelson 1965a ; and Mandelbrot 1966 ; explained stock price movements in a similar manner. Their work, together with the empirical and theoretical research of Fama 1965, 1970 ; , led to the development of the efficient market hypothesis. According to this hypothesis, stock prices already incorporate all available information. Otherwise, predictable price movements would generate possibilities for speculators to gain risk-free profits. In efficient markets such speculators always exist and they always take advantage of the presented opportunities, thus causing the opportunities to disappear. Prices following a Brownian motion can become negative. To overcome this shortcoming, Samuelson 1965b ; formulated the price movements of a single stock as a geometric Brownian motion. For the price of a stock i following a geometric Brownian motion Si t, ; ei Bi t, ; where Bi t, ; is a one-dimensional Brownian motion and i R and i R are parameters describing stock i. A stochastic process that follows a and etoposide.
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Increasingly, there has been a great deal written about so-called "pay-for-performance" programs. Wellmark Blue Cross and Blue Shield is focusing its efforts on collaborating with providers on quality of care initiatives to give greater attention on improving health care. Currently, there are two unique programs under way in South Dakota: Recognize and Reward Best Practices Centers of Excellence Improving health care quality through collaborations between Wellmark and its contracting physicians and hospitals is the foundation for these two programs. Ultimately, it is the goal that these programs will lead to better outcomes and improved health for your employees. In addition, Wellmark believes these initiatives will help drive re-engineering of the health care system through the following changes: Public disclosure of provider performance data Health plan benefit design changes Provider payment system changes Provider network design changes Recognize and Reward Best Practices Recognize and Reward Best Practices is a primary care clinic-based pilot program to provide incentives to practitioners who use evidence based protocols. The program shares medical and pharmacy administrative claims data with physicians. The data allows physicians to benchmark practice patterns against their peers, national guidelines, and other appropriate comparative measures. Pilot programs started this summer in South Dakota. Nine providers are participating in programs at Avera McKennan clinics in Brookings and Flandreau. Another 14 providers are participating in a pilot program at the Sioux Valley clinics in Sioux Falls. The first pilot programs began in the fall of 2004 in Iowa -- one in Cedar Rapids and one in Des Moines. Recognize and Reward Best Practices is a collaborative effort between Wellmark and the physicians. The pilot sites are responsible for driving participation and results in their communities. Physician leaders at each site work with Wellmark to establish the disease conditions and the interventions to focus on and measure. These are called "clinical suites." Diabetes, asthma, heart disease, and hypertension are some of the clinical suites that have been established. In addition, local physician leaders encourage other physicians in their practice to participate in the program on a voluntary basis. Physician leaders then work with Continued on page 6.
These reports will be comprehensive and suitable for dissemination. Within 12 months we expect to publish some of them in conferences or workshops. We have produced the following reports see Deliverable D1.1 ; : [ALZ02a] published in ECOOP 2002, [ALZ02b] published in PPDP 2002, [DLE02] accepted to ESOP 2003, [MF02] accepted to FOSSACS 2003, [AFMZ02]; [FMP02b], [BBV02a] published in Coordination 2002, [BBV02b]. X ; Choice of sub-theories for dynamic assembly suitable for integration into a general theory. WP1 consists of two strands. The first strand, oriented towards WP4, takes Java and partly C# ; as a paradigmatic example of environment supporting notions relevant for dynamic software assembly, such as separate compilation, dynamic loading, binary compatibility. Here we plan to integrate models for different notions, e.g., the formal frameworks for separate compilation in [ALZ02a] and [ALZ02b] and that for dynamic linking in [DLE02]. The second strand, oriented towards WP5, is more theoretical and more appropriate for combination with core calculi produced by other GC projects. Here we have focused on two important language features: staging and mixin modules. In particular, we plan to produce a monadic metalanguage with staging and mixin modules by integrating [MF02] and [AFMZ02]. We also plan to relate the two strands, by abstracting some aspects considered in the first strand within the more general frameworks proposed in the second strand. However, some aspects, like run-time verification and type-checking, will be considered only when WP5 is in a more advanced stage. WP2: Flexible and Compositional Type Systems C ; Reports on various new type systems with principality. Q ; These reports will be comprehensive and suitable for dissemination. Within 12 months we expect to publish some of them in conferences or workshops. We have produces the following reports see Deliverable D2.1 ; : [Wel02] published in ICALP 2002, [CD02b] published in VMCAI 2002, [CDGS03] to appear in CATS 2003, [AW02], [MZ02], [Dam02], [dL02a], [CR02a]. X ; Choice of the most interesting calculi for supporting type systems with principality and the corresponding type inference algorithms. For very precise type analysis of standard programming language features, we have chosen to focus on the approach of [Dam02] using rank-2 intersection types with new features for better analysis of mutually recursive definitions, conditional expressions e.g., if-expressions and match-expressions ; , and local definitions. We will also consider whether new techniques involving expansion variables [KW02] can be integrated. This is a further step towards the use of intersection types in real programming languages. We expect to investigate adding support for user-supplied type information and link-time inter-module type checking. We will be developing a prototype implementation. For very precise type analysis of mobility, we have chosen to build on the calculus M3 [CDGS03] designed in Univ. di Torino ; and ideas for precise and flexible types from [AW02] designed by Heriot-Watt Univ. ; . The calculus M3 , developed in WP2 in interaction with MIKADO, meets many of the requirements a core calculus suitable for the above purpose must satisfy: simplicity its operational semantics is an intuitive reduction semantics in the well-established tradition of calculi for concurrency, distribution and mobility, with no new exotic primitives ; , expressive power the other most known calculi can be coded in it ; , extensibility it can be smoothly extended with new constructs, some of which can already be partially coded in the calculus ; , ability to support compositional type systems it already comes with a system with principal typings ; . Its present type system, however, is too poor to be able to express the properties envisaged in the project. It therefore needs to be augmented with a richer type language and more powerful inference algorithms, which we intend to develop with help from the ideas of [AW02]. WP3: Calculi for Object Evolution C ; Reports on new calculi allowing modification of the object code at run-time and new prototype languages allowing modification of classes at run-time. Q ; These reports will be comprehensive and suitable for dissemination. Within 12 months we expect to publish some of them in conferences or workshops. We have produced the following reports see Deliverable D3.1 ; : [DDDG02b] published in TOPLAS, [AD02b] presented at the workshop USE 2002, [BDG02] published in F-WAN 2002, [BBV02a] published in Coordination 2002, [BBV02b], [DDDG02a], [CGHL03], and [HL03].
His findings, Harper stated: My examinations disclosed no individual characteristics establishing that Exhibit 47 [the Kennedy neck bullet] and Exhibit 54 [the Weisel bullet] had been fired by the same gun. In fact, my examinations disclosed that bullet Exhibit 47 has a rifling angle of approximately 23 minutes 14% ; greater than the rifling angle of bullet Exhibit 54. It is, therefore, my opinion that bullets 47 and 54 could not have been fired from the same gun. Harper's findings sent shockwaves, and may well have provided the impetus to the elevation of Wolfer to the head of the Crime Lab. Once Wolfer became the head of the Crime Lab, would not his word seem by the uninformed to carry more weight? Blehr and Harper failed in their efforts to overturn Wolfer's appointment. LAPD Chief Ed Davis hailed Wolfer as "the top expert in the country." Klaber and Melanson have a whole chapter of their book devoted to Wolfer, and wrote this about his qualifications: At the time of the [Sirhan] trial, there was no specific major or grade point average required for the position of LAPD criminalist, and Wolfer's studies at USC seemed to relate tangentially at best to his chosen profession. As a zoology major he received more C's than all other grades combined, and he received five D's, including one in his major and two in chemistry. He also had a history of offering inflated credentials to bolster his perceived expertise, something that would come to haunt him in a few years.25 But the fact that the bullets could not be matched to the gun or to each other was only a piece of what Harper found. He found another element when he started looking at the test bullets. They came out of an envelope with the wrong gun number on it. The Sirhan gun had a serial number of H53725. The serial number for the gun on the evidence envelope, however, read H18602. Harper used an analogy to demonstrate the significance of this problem: "Let us ponder a simple analogy, " Harper, 72, said recently. "Let's say that one day you become ill and your doctor sends you to a hospital for a biopsy test.
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Before submitting the paper copy of your manuscript to the Journal of Managed Care Pharmacy, please check to see that your package includes the following: u Cover letter u Manuscript: prepared in 12-point type, 1.5 line spacing, including u abstract: no more than 650 words u keywords: follows the abstract u references: cited in numerical order as they appear in the text use superscript numbers ; and prepared following modified AMA style; do not include footnotes in the manuscript u tables and figures generally no more than a total of 6 ; . Submit referenced tables and figures on separate pages with titles and captions, as necessary ; at the end of the manuscript; match symbols in tables and figures to explanatory notes, if included. May use 10-point font. u Disclosures and conflict-of-interest forms: completed and signed author attestation forms available at amcp clearly indicate source s ; of funding and financial support. Note: Please do not include author identification in the electronic manuscript document. For "Manuscript Submission Checklist" and "Peer Review Checklist, " see amcp, because diuretics.
[8] E. B. Baum and D. Boneh. Running dynamic programming algorithms on a DNA computer. In Proceedings of the Second Annual Meeting on DNA based Computers, 1996. [9] D. Beaver. Computing with DNA. Journal of Computational Biology, 2 1 ; : 18, 1995. [10] D. Beaver. Molecular computing. Technical report, Penn State University, January 1995. [11] D. Boneh, C. Dunworth, and R. J. Lipton. Breaking DES using a molecular computer. Technical report, Princeton University, 1996. [12] D. Boneh, C. Dunworth, R. J. Lipton, and J. Sgall. On the computational power of DNA. Technical report, Princeton University, 1995. [13] D. Boneh and R. J. Lipton. Making DNA computers error resistant. Technical report, Princeton University, 1996. [14] W. Cai, A. E. Condon, R. M. Corn, E. Glaser, Z. Fei, T. Frutos, Z. Guo, M. G. Lagally, Q. Liu, L. M. Smith, and A. Thiel. The power of surfaced-based DNA computation. Technical report, University of Wisconsin, July 1996. [15] E. Csuhaj-Varj , R. Freund, L. Kari, and G. P un. DNA u a computation based on splicing: universality results. In Proceedings of the First Annual Pacific Symposium on Biocomputing, 1996. [16] E. Csuhaj-Varj , L. Kari, and G. P un. Test tube distributed u a systems based on splicing. Computers and AI, 15 23 ; : 211 232, 1996. [17] K. Culik II and T. Harju. Splicing semigroups of dominoes and DNA. Discrete Applied Mathematics, 31: 261277, 1991. [18] J. Dassow and V. Mitrana. Splicing grammar systems. Computers and AI, 15 23 ; , 1996. [19] K. L. Denninghoff and R. W. Gatterdam. On the undecidability of splicing systems. International Journal of Computer Mathematics, 27: 133145, 1989. [20] R. Freund. Splicing systems on graphs. In Proceedings of Intelligence in Neural and Biological Systems, pages 189 194, May 1995. [21] R. W. Gatterdam. Splicing systems and regularity. International Journal of Computer Mathematics, 31: 6367, 1989. [22] F. Guarnieri, M. Fliss, and C. Bancroft. Making DNA add. Science, 273: 220223, July 1996. [23] J. Hartmanis. On the weight of computations. Bulletin of th European Association for Theoretical Computer Science, 55: 136138, February 1995. [24] T. Head. Formal language theory and DNA: an analysis of the generative capacity of specific recombinat behaviours. Bulletin of Mathematical Biology, 49: 737759, 1987. [25] T. Head. Splicing schemes and DNA. Nanobiology, 1: 335 342, [26] P. D. Kaplan, G. Cecchi, and A. Libchaber. Molecular computation: Adleman's experiment repeated. Technical report, NEC Research Institute, 1995. [27] R. Karp, C. Kenyon, and O. Waarts. Error resilent DNA computation. Technical report, Ecole Normale Sup rieure e de Lyon, September 1995. [28] S. A. Kurtz, S. R. Mahaney, J. S. Royer, and J. Simon. Active transport in biological computing preliminary version ; . In Proceedings of the Second Annual Meeting on DNA based Computers, 1996 and microzide.
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