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DIALOG 0886614104 ; is published three times a year by IMAG. Supported by an educational grant from Teva Neuroscience. 2003. All rights reserved. None of the contents may be reproduced in any form without prior written permission of the publisher. The opinions expressed in this publication are those of the contributors and do not necessarily reflect the opinions or recommendations of the publisher, editor, advisory board or sponsor. Consult your physician or health care professional about any medications or lifestyle changes discussed in this publication. DIALOG is made available free of charge as a public service to individuals with multiple sclerosis. Information on subscriptions, change of address or any other correspondence should be addressed to: Editor, DIALOG, 345 Victoria Ave., Suite 301, Westmount, Quebec, H3Z 2N2; fax 514 ; 369-7878. Or email Dialog at: info imag-media . All members of the Shared Solutionsprogram in Canada automatically receive a subscription and need not resubscribe. DIALOG is now available online at: sharedsolutions and cipro.
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Information on the impact of endometriosis on HRQL in adolescents is limited. Adolescents are at increased risk for developing endometriosis in the presence of genital tract anomalies, such as congenital uterine anomalies, vaginal septa, and imperforate hymen38. Endometriosis, laparoscopically confirmed, reportedly occurs in 2538% of adolescents with a history of CPP; with up to 70% cases reported in adolescents refractory to pharmacologic management39. Pain commonly experienced in endometriosis can have both behavioral and psychosocial consequences in adolescents. Adolescents with endometriosis may experience depression, fear, or anxiety. Furthermore, endometriosis can adversely affect daily life activities such as school attendance. The most recent published.
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9. Pfleger K, Maurer HH, Weber A. Mass Spectral and GC data of drugs, poisons, pesticides, pollutants and their metabolites. Weinhein: VCH; 1992. 10. Silva OA, Yonamine M, Antunes CGL, Greve JMD, Midio AF. Fenproporex abuse by truck drivers in Brazil. In: SOFT-TIAFT 1998. Program and Abstracts. Albuquerque: Society of Forensic Toxicologists, International Association of Forensic Toxicologists; 1998. p. 137. [Abstract, n. 119]. 11. United Nations Office on Drugs and Crime. Global illicit drug trend 2003. Vienna; 2003. 12. Verstraete AG, Pierce A. Workplace drug testing in Europe. Forensic Sci Int 2001; 121: 2-6. Yonamine M, Silva OA. Confirmation of cocaine exposure by gas chromatography-mass spectrometry of urine extracts after methylation of benzoylecgonine. J Chromatogr B 2002; 773: 83-7.
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SLEEP DYSREGULATION IN COCAINE DEPENDENT MEN DURING ACUTE ABSTINENCE Valladares EM, 1, 2, 3 Eljammal SM, 1 Lee J, 1 Newton TF, 1 Fong T, 1 Ehlers CL, 1 Irwin MR1 1 ; Cousins Center for Psychoneuroimmunology, UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA, 2 ; Neurobiology, UCLA Geffen School of Medicine, Los Angeles, CA, USA, 3 ; Physiological Sciences, UCLA Geffen School of Medicine, Los Angeles, CA, USA Introduction : Sleep disturbance is one of the most prominent complaints of cocaine dependent patients with over 70% of subjects reporting disordered sleep during recovery. However, few polysomnography studies have been conducted in cocaine dependent individuals and conclusions are limited by small sample sizes, clinical heterogeneity, and failure to include controls who are matched on potentially confounding variables. Methods : This study evaluated 17 males with cocaine dependence and 14 matched controls. The groups did not differ in: age, body mass index, ethnicity, marital status, or the time elapsed since their last alcohol consumption. Cocaine dependent men were acutely abstinent having actively used cocaine within the last 2.5 days prior to sleep assessment. Continuous polysomnography data was acquired for three consecutive nights at the UCLA General Clinical Research Center. EEG sleep was scored in accordance to Rechtschaffen and Kales criteria. Data are presented for the third night. Results : As compared to controls, cocaine dependent men showed increases of stage 1 sleep 34.0 18.0 min vs. 22.7 10.9 min; p 0.05 ; , loss of stage 3 0.4 0.8 min vs. 18.9 18.8 min; p 0.05 ; and of stage 4 sleep 0.0 0.0 min vs. 1.9 2.8 min; p 0.05 ; , and decreases in REM latency 34.5 23.8 min vs. 69.2 56.1 min; p 0.05 ; . Differences in sleep continuity measures were not found between the two groups. Conclusion : These data are among the first to show that chronic cocaine dependence is associated with a loss of slow wave sleep and increases in REM pressure in men. Given the important role of sleep in the homeostatic regulation of the immune and autonomic systems, these data have important implications for understanding the health risks in persons who chronically use cocaine, for example, carisoprodol codeine.
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