Abstract. There is a common availability of classification terms in online text collections and digital libraries, such as manually assigned keywords or key-phrases from a controlled vocabulary in scientific collections. Our goal is to explore the use of additional classification information for improving retrieval effectiveness. Earlier research explored the effect of adding classification terms to user queries, leading to little or no improvement. We explore a new feedback technique that reranks the set of initially retrieved documents based on the controlled vocabulary terms assigned to the documents. Since we do not want to rely on the availability of special dictionaries or thesauri, we compute the meaning of controlled vocabulary terms based on their occurrence in the collection. Our reranking strategy significantly improves retrieval effectiveness in domain-specific collections. Experimental evaluation is done on the German GIRT and French Amaryllis collections, using the test-suite of the Cross-Language Evaluation Forum CLEF.
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The drugs are effective only if they are consumed by the patient. Nonadherence to the prescribed treatment is a crucial factor in the genesis of MDR-TB. The directly observed treatment, short-course DOTS ; strategy, which has been endorsed by the WHO as the only effective way to control TB, has to some extent addressed these problems.14 However, when facilities for mycobacterial culture and sensitivity testing are not available, therapeutic decisions are most often made by algorithms or inferences from previous treatment. Although the benefits of DOTS in reducing the transmission and incidence of both drug-susceptible and drug-resistant TB even in settings with moderate rates of MDR-TB have been well documented, 15 it has been observed that the `programmatic approach' to the management of patients who do not respond to treatment may fail in certain settings.16, 17 The virulence of the organism e.g. W-Beijing genotype ; , the potential contribution of multidrug transporters and the association of certain human leukocyte antigen HLA ; haplotypes have also been implicated in the genesis of MDR-TB.1, 2 Although HIV infection per se does not appear to be a predisposing factor, other associated factors such as increased susceptibility to TB, increased opportunity to acquire TB due to overcrowding, alcoholism and substance abuse, along with poor adherence to the prescribed anti-TB drugs, exposure to patients with MDR-TB due to increased hospital visits and malabsorption of anti-TB drugs resulting in suboptimal therapeutic blood levels despite strict adherence to the treatment regimen potentially increase the chance of development of MDR-TB in these patients.1, 2 Diagnosis of Multidrug-resistant Tuberculosis MDR-TB is essentially a laboratory diagnosis. In the majority of centres, especially those in the developing world, Lowenstein-Jensen culture using the absolute concentration method, the resistance ratio method and the proportion method have been conventionally used for drug-sensitivity testing.1, 2 With these methods, a minimum period of 68 weeks is required before sensitivity results are available. With the availability of modern methods of diagnosis such as radiometric e.g. BACTECTM ; and molecular methods, the diagnosis of MDR-TB can be made much earlier; however, these tests are seldom available in the field setting in countries, for example, amaryl 3 mg.
Here are many different types of oral medications used to treat Type 2 diabetes, and sometimes Type 1 diabetes in addition to insulin. However, medication is no substitute for a healthy diet and exercise! Without attention to other risk factors such as smoking, obesity, hypertension and cholesterol, even perfect control of blood glucose may not reduce diabetesrelated illness. People with Type 2 diabetes essentially have three problems that are addressed by oral diabetic medication: inadequate secretion of insulin from the pancreas resistance to the effects of insulin in tissues too much production of glucose by the liver Types of Diabetes Medications Sulphonylureas are medications that increase pancreatic insulin secretion. Examples include glibenclamide Daonil, Glimel ; , gliclazide Diamicron, Glyade, Melihexal ; , glimepiride Amaryl, Dimirel ; and glipizide Melizide, Minidiab ; . These medications unfortunately increase the chance of weight gain. There is also the.
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The cross-language evaluation forum CLEF [11] ; addresses four different crosslingual information retrieval tasks: monolingual, bilingual, multilingual, and domain-specific retrieval. For domain-specific retrieval at CLEF, the scientific collections of GIRT German ; and Amaryllis French ; are used. Table 1 gives some statistics about the test collections. Notice that the Amaryllis queries are and amitriptyline.
Glyburide eg. Diabeta ; or gliclazide Diamicron ; or glimepiride Amarhl ; metformin HCL Glucophage ; rosiglitazone and metformin combination Avandamet.
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Sales of Insuman in 2000 were 4 156 million, an increase of 59.0% + 58.6% activity variance ; from 4 98 million in 1999. Aventis initiated a changeover from a semi-synthetic insulin product line to a recombinant human insulin line in 1999. Insuman is a state-of-the-art recombinant human insulin for the treatment of type 1 and type 2 diabetes. It is identical in structure to the insulin normally secreted by the human pancreas. This drug is available in a variety of formulations with varying ratios of regular insulin and NPH insulin. Insuman offers patients a convenient method to achieve optimum metabolic control when used with the OptiPen Pro or OptiSet patented insulin delivery systems and amoxicillin!
Rearrangement of glycinate esters, the other on an intramolecular Heck reaction. The route to pancratistatin and to its unnatural analogs is based on the metal-mediated cyclotrimerization of acetylenic substrates of type 3. The core of this Amaryllidaceae constituent has been attained in the initial stages of this project. The details of the synthetic endeavours toward these and other heterocyclic targets will be disclosed with emphasis on practicality, brevity, and efficiency as guiding principles of enviromentally benign manufacturing of relevant compounds. Keywords: Morphine, pancratistatin, total synthesis of alkaloids, cyclotrimerization, enzymatic oxidation of aromatics, toluene dioxygenase.
Clinical manifestations of the indolent ulcer comprise a superficial corneal ulcer that is nonresponsive to appropriate medical therapy. These ulcers are surrounded by loose, nonadherent epithelial margins and lacrimation and blepharospasm are often present. Corneal vascularization may develop with chronicity. The diagnosis of an indolent ulcer is confirmed with positive fluorescein staining that continues under the loose, nonadherent edge of the ulcer. It is important to assess the horse for other causes of a non-healing ulcer such as dry eye, ectopic cilia, and conjunctival and corneal foreign bodies, since correction of these factors are necessary for healing and amoxil.
Advertising. Consumers could therefore be misled by the very advertising that FDA intended to be corrective. Although FDA characterizes the "regulatory letters" and other statements of FDA officials as merely "advisory, " these communications have real practical consequences. As we discuss in greater detail in our report, WLF has determined that FDA's current regulation of prescription drug promotion: Deprives patients and consumers of truthful, non-misleading scientific information without adequate justification and in violation of the First Amendment; Irrationally compels drug manufacturers to disclose drug risk information twice in the same advertisement, misleading consumers and health care practitioners into believing that products are riskier than they actually are; and Improperly relies on corrective advertising, which FDA has never determined to be effective in addressing misleading promotion and which is used routinely by FDA without any analysis of whether the allegedly deceptive manufacturer advertisement did, in fact, deceive anyone.
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With biotech companies going out of business, big pharmaceutical companies consolidating their labs, and manufacturers discounting slightly out of date or overstocked equipment, a bounty of opportunity exists around the business of buying or selling used lab equipment. Many companies deal specifically with used scientific equipment in Canada and worldwide. Manufacturers argue, however, that there is little to protect those who buy second hand: there are no guarantees the equipment is still in working order, and often the warranty has expired. "There is not just one dimension [in the buying process for used equipment]. What gives the highest value for the dollar, all the time we are seeking that, " says Yves Jobin, supply manager, grants with the University of Ottawa. His buying philosophy in a nutshell? Cost, compared to benefit, will make or break any sale. When equipping the uni and aricept.
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Or non-emergency telephone lines. Contractor shall ensure staffing of the EMS Communications Center will never be less than five 5 ; Personnel. SECTION 403. VEHICLES AND EQUIPMENT Contractor shall, at its own cost and expense, furnish all Authority-approved Vehicles and equipment necessary and essential to the performance of this Agreement. Such Vehicles and equipment shall be subject to the terms and conditions of the Equipment Agreement attached as Appendix U hereto. SECTION 404. ON-SCENE EQUIPMENT EXCHANGE PROGRAM When a First Responder in the course of preparing a Patient for Transport employs equipment listed in Appendix O, as the same may be amended from time to time, Contractor's Personnel shall exchange with that First Responder that same item of equipment from its own on-board inventory on a one-for-one basis. If such equipment is not available, First Responder may request delivery of such equipment by an EMS Supervisor Unit or Medical Supply Unit through the EMS Communications Center. The Authority shall furnish replacement items of equipment, listed in Appendix O, when replacement is necessary due to normal wear and tear. Contractor shall be responsible for repair or replacement of equipment furnished by the Authority and damaged or lost by accidental loss, theft, abuse or neglect of Contractor's employees or agents. Contractor shall be responsible for designing, implementing, and operating an inventory control record-keeping system capable of accurately tracking the quantities of equipment items included in the on-scene equipment exchange program, as well as disposable supplies and equipment. Replacement of items lost from First Responder inventories shall not be Contractor's responsibility.
Go to an Annual Meeting of the IAL or to local support group meetings and you will rarely see a single laryngectomee who does not cover his or her stoma. While many may cover up because of concern for their appearances, there are solid medical reasons to keep our stomas covered. The consensus of experts reinforced by the best clinical evidence available supports the wearing of stoma covers, and there is no evidence that suggests that laryngectomees are as well off without them. If laryngectomees choose Respiratory system before and after not to cover their stomas laryngectomy they would be making the decision in spite the best medical advice. It is just not an option, according to the experts. Stoma covers help to replace functions previously carried out by the nose and mouth by.
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Implementation of our new organisational scheme. PLIVA decided not to charge previously announced restructuring costs related to the acquisition of AWD through the profit and loss account, but to decrease the net asset value of the acquired company, in accordance with IAS No 22. In the year 2001, the launch of new and transferred products, as well as the continuation of promotional activities, led to growth in Sales and Distribution S&D ; costs by 28.1% to HRK 755.5 m. During the fourth quarter of 2001, S&D costs reached HRK 241.6 m, growing by 26.0%. The consolidation of AWD affected growth in G&A and S&D costs as well. The advanced stages of clinical trials induced Research and Development R&D ; costs to increase by 16.7% to HRK 423.4 m in 2001, representing 8.8% of healthcare revenues. However, in the fourth quarter of 2001, R&D costs rose by 51.2%, to HRK 141.9 m, representing 9.2% of healthcare revenues. The inconsistent growth pattern between quarters is due to milestone dynamics. Earnings before Interest and Tax EBIT ; increased to HRK 1, 568.2 m growing by 10.7%, or by 9.6% on a comparable basis in the year 2001, as savings from our cost reduction programme offset increased costs from our intensive sales and distribution activities related to new and transferred products and costs related to establishing the Western European sales network. The EBIT margin was 29.7% on a yearly basis. In the fourth quarter, EBIT reached HRK 538.9 m increasing by 36.5% with a margin of 32.2%. Furthermore, on a comparable basis EBIT rose by 24.8% to HRK 556.5 m, with a margin of 33.3%. Earnings before Tax EBT ; amounted to HRK 1, 483.6 m slightly increasing by 1.9% on a yearly basis, growing, however, by 9.7% to HRK 508.6 m in the fourth quarter of 2001. EBT was highly affected by financial loss from the sale of the remaining foodstuffs business in June 2001, financial expense from ESOP transaction HRK 2.75 m ; and unfavourable exchange rate movements, which increased financial losses to HRK 84.6 m in the year 2001. As a result of a lower corporate tax rate introduced in Croatia at the beginning of 2001, effective tax rate for 2001 decreased to 25.7% in comparison with 29.5% for 2000 excluding discontinued business and one-time items in both years ; . Net Income reached HRK 1, 095.8 m in the year 2001, declining by 3.6%, but up 9.3% on a comparable basis, excluding the overpaid tax return in the third quarter of 2000 and reflecting the current lower corporate tax rate of 20% in Croatia ; . The net margin was maintained at 20.8%. In the fourth quarter of 2001, net income decreased by 7.4% to HRK 377.6 m with a net margin of 22.6%. On a comparable basis, net income rose by 4.7% to HRK 394.5 m, maintaining a margin of 23.6%. Given the average number of shares outstanding in each year, Earnings per Share EPS ; increased by 12.9% from HRK 52.83 to HRK 59.64 on a comparable basis or decreased by 0.4% from HRK 57.69 to HRK 57.44 on a reported basis ; . In the fourth quarter, EPS moved from HRK 19.18 to HRK 21.07 on a comparable basis or declined by 2.9% from HRK 20.76 to HRK 20.17 on a reported basis and ambien.
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In fiscal 2004, more than 3, 000 pregnancy tests were performed on more than 1, 500 Texas foster children at a cost of more than $27, 000. These children received pregnancy tests while having a variety of accompanying diagnoses including abdominal pain, absence of menstruation, child sexual abuse, pelvic inflammation, urinary tract infections and venereal disease. Hundreds of pregnancy tests were given to foster children even when the accompanying diagnoses did not suggest a need for the test. For example, children diagnosed with hay fever, bipolar disorder, depression, drug abuse, poor eyesight, medication poisoning, strep throat and even ingrown nails also received pregnancy tests. Such instances may represent questionable claims for services that were billed and never provided. $400, 000. The costs included some costs for deliveries as well as for doctor's office visits, blood typing tests, sexually transmitted disease tests and genetic exams.
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But will it? There is ample literature to support the concept that excessive copays cause suboptimal use of essential medications.11, 14, 15 One recent study, for example, found that doubling the copay for diabetes drugs led to a 23% decrease in per-member per-year drug days supplied.15 The American Diabetes Association also warns explicitly about the short-sightedness of erecting cost barriers to diabetes medications see Sidebar, "Tight Cost Controls May Be Barrier to Diabetes Management" ; .12 Still, the actual return on investment from lowered copays is less well documented and would, anyway, vary considerably from plan to plan and company to company. Thus, the polestar for this effort at Pitney Bowes remains the internal company evidence linking low prescription fill rates to high subsequent costs. For diabetes, the major benefit design change involved moving a number of tier 2 and 3 drugs to tier 1. These included insulin products such as Humalog, Humulin, Lantus, Novolin, and NovoLog as well as oral agents such as Actos pioglitazone ; , Amartl glimepiride ; , Avandia rosiglitazone ; , Avandamet rosiglitazone metformin ; , Glucotrol XL glipizide extended release ; , Glucovance glyburide metformin ; , Prandin repaglinide ; , Precose acarbose ; , and Starlix nateglinide ; . No judgments were.
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In December 2005, in response to ongoing confusion about the eligibility of dialysis patients for hospice care, a Medicare memo was released clarifying benefit coverage. In a nutshell, if the terminal condition for which hospice care was elected is not ESRD or ESRD-related, the beneficiary can receive both hospice and ESRD benefits. As an example, a beneficiary with terminal cancer CAN continue to dialyze while receiving hospice benefits. The Medicare memo regarding this can be accessed on-line at: : ugsmedicare providers medica re memos 2005 documents Medicare MemoDecember 2005R On April 1, 2006, the new Medicare policy regarding Epogen and Aranesp becomes effective. The current policy involved a post-payment review based on a 90-day rolling average of the hematocrit, with an action level set at hematocrit of 37.5. With input from the ESRD community, CMS reviewed and revised the policy such that, on the date of implementation, CMS will increase the action level for monitoring to hematocrit of 39.0 or hemoglobin of 13.0. For labs exceeding the action level, Epogen Aranesp dosage should be reduced by 25%. If dose is correctly reduced, claim will be paid. If dose is not reduced appropriately, CMS will only pay for the dose that should have been given i.e., CMS will pay as though the dose had been decreased by 25% ; . Complete details for the new policy can be accessed on-line at: : new.cms.hhs.gov apps media press release ?Counter 1723 While many of you may already be aware, the old, no-frills ICD-9 code of 585, chronic renal failure was "retired" on October 1, 2005. The new ICD-9 code for ESRD is 585.6, with codes 585.1-585.5 used to specify corresponding stage of chronic kidney disease. The CMS notice can be accessed online at: : cms.hhs.gov MedlearnMattersArti cles downloads MM4108 PRODUCT RECALLS 9 28 05--Baxter Meridian hemodialysis machine recalled due to kinking of blood tubing. One death and one serious injury associated with this recall. Issue corrected by changing bloodline configuration. Specific information about this recall can be accessed at: : fda.gov oc po firmrecalls baxter12 05 9 19 Baxter Colleague infusion pump recalled due to battery issue. Baxter has issued a letter addressing measures that can be taken to minimize battery failure occurrence. See link below for more information. Online information about various FDA recalls can be accessed at: : fda.gov cdrh recalls DIABETES-RELATED NEWS On Jan. 27, the FDA approved Exubera, the first inhaled form of insulin. FDA information can be accessed on-line at: : fda.gov bbs topics news 2006 NEW01304 In November, the FDA approved Avandaryl, a combination of Avandia and Amaryl, two oral anti-diabetic medications with different mechanisms of action. More information is available at: : drugs avandaryl INDUSTRY-RELATED NEWS Vasca, maker of the LifeSite Hemodialysis Access System, announced the closure of the company, effective Jan. 31, 2006. As of that date, the LifeSite will no longer be available, though needles used with this access will remain available through Medisystems or their distributors. For more information, see: : vasca and click on customer letter. CDC NEWS New tuberculosis transmission prevention guidelines for healthcare facilities were released in December. Full text available at: : cdc.gov mmwr preview mmwrhtml rr5417a1 2005-2006 Adult immunization recommendations released in October. Available: : cdc.gov mmwr preview mmwrhtml mm5440Immunizationa1.
Fig. 4. One of 5000 equally parsimonious trees generated by cladistic analysis of successively weighted trnL-F sequence matrix for Amaryllidaceae and other Asparagalean genera. Numbers above branches are branch lengths. Bootstrap plain ; and jackknife boldface ; percentages are below branches supported by one or both. A white bar across a branch signifies lack of resolution in the strict consensus tree of the 5000 trees. The tree is continued in Fig. 3.
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