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A new treatment paradigm for early type 2 diabetes, described in the May issue of Diabetes Care, involves inhibition of dipeptidyl peptidase IV DPP IV ; . "This study provides the first evidence that pharmacological DPP IV inhibition is feasible for the treatment of type 2 diabetes in humans", "write Bo Ahren, MD, from Lund University in Malmo, Sweden, and colleagues. Although glucagon-like peptide-1 GLP-1 ; has potential for treatment of type 2 diabetes, its short halflife prompted investigation of inhibitors of the GLP-1degrading enzyme DPP IV, which improve glucose tolerance in insulin-resistant rats and mice. This double-blind, multicenter trial involved the selective, orally active DPP IV inhibitor NVP DPP 728. Over the 4-week treatment period, 61 men and 32 women with diet-controlled type 2 diabetes mean age, 64 years ; received placebo or the inhibitor at a dose of 100 mg three times daily or 150 mg twice daily. There were no significant adverse effects. Compared with placebo, NVP DPP728 at 100 mg three times daily reduced mean fasting glucose by 1.0 mmol L, prandial glucose excursions by 1.2 mmol L, and mean 24-hour glucose levels by 1.0 mmol l all P .001 ; . Reductions were similar in subjects receiving 150 mg twice daily, and mean 24-hour insulin levels were reduced by 26 pmol L in both active treatment groups. An unexpected benefit was that HbA1c in the combined active treatment groups decreased by 0.6% P .001 ; . "There was no difference between a three-times-daily treatment schedule versus a twice-daily treatment schedule with NVP DPP728, indicating that either dosing regimen could probably be used with equal efficacy", the authors write. "Further long-term studies will be needed to examine the long-term effects of DPP IV inhibition as well as to fully understand the mechanism of the effects and to define the use of this approach in patients with more advanced diabetes and in combination with other antidiabetic drugs." Diabetes Care. 2002; 25 5 ; : 869-875 TRIAL OF ARTFICIAL PANCREAS SET FOR LAUNCH Clinical trials will begin next month for a prototype artificial pancreas that should enable patients with type 1 diabetes to have more controlled levels of blood glucose with fewer episodes of hypoglycemia than are!
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Cheryl-Ann Tubby joined AES in March 2000. What led you to the American Epilepsy Society? Working in a health-related organization is attractive to me. I came to AES after six years at Prevent Blindness Connecticut, a non-profit health agency dedicated to helping people identify signs of eye diseases that could lead to blindness. I really enjoyed working with the volunteers and helping people, whether it was providing education about the signs of eye diseases, answering questions, providing screening programs, or directing them to appropriate services. What have you been working on since you joined the AES staff? My main role is to provide services to the members. This includes helping committees keep their projects running, updating members about what's going on, and coordinating committee meetings. One project I've been working on is an update to the Directory of Prescription Assistance Programs. When the Practice Committee wanted to update the guide, somebody needed to call all the drug companies to get more details about their programs. I chased the information down, wrote it up and got it back out to the committee. That's what I'm here for--to help committees get their projects accomplished. Tell us about some of your other AES projects. The biggest one--I started on it almost my first day at AES--was the first AES Annual Report. It was a great way to meet a lot of the AES committee chairs, as well as a way to learn about the organization. I'm also working on updating the Leadership Guide, which is a manual distributed to board members and committee chairs. It describes the different committees, the board positions and their jobs, what their terms are, what their responsibilities are-- it lays it all out. That should be available soon on the AES Web site. How have you been received by the AES membership? Everyone has been very enthusiastic. That's great when you're working with a group of volunteers, especially volunteers who are professionals. They often don't have a lot of time to give to volunteer activities even though they're willing. Most of the AES folks I've worked with have been wonderful. They take their phone calls and answer their e-mail. They really are involved in AES. It's not just a name on the letterhead; they want to contribute. They make my job easier. Everybody appreciates what I'm doing, which is nice, too. It's always helpful when someone says thank you! What do you expect next? I'm hoping to get more involved in the membership issues of recruiting and retention. That will be a big project. I've also launched the new SIGnals column in AES News, to get the SIGs more active on a yearround basis. And we started a bulletin board for SIGs on the AES Web site as well. And you'll be attending your first AES Annual Meeting in Los Angeles? Yes, that's right. I know it's going to be 12and 14-hour days, but I'm really looking forward to it. It's a chance to really see what happens in AES, attend more of the committee meetings and get to know more of the people. I don't think I've ever been to a conference with 3000 people involved. It's going to be really exciting.
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Since graduating from the University of Otago, Dr Ed Gane trained in Hepatology at the Institute of Liver Studies, Kings College School of Medicine, London, where he completed his thesis on the pathogenesis of hepatitis C. On his return to New Zealand in 1996, he became Chief Hepatologist for the New Zealand Liver Transplant Unit and Auckland Hepatoma Clinic and Hepatitis clinics. He is the Clinical Advisor to the National Hepatitis B Screening Program and Principal Investigator for several clinical trials of antiviral therapies for HBV and HCV. Associate Professor Gane is vice-president of the Asia Pacific Association for the Study of the Liver and member of the American Association for the Study of Liver Diseases, the Transplant Society of Australia and New Zealand and Gastroenterology Societies of New Zealand and Australia. Associate Professor Gane has published over 50 first author papers, including in the Lancet, New England Journal of Medicine, Gastroenterology and Hepatology. New Zealand Liver Transplant Unit Auckland Hospital AUCKLAND, NEW ZEALAND, for instance, alphagsn 15.
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