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Arising from this practice. According to the Department of Justice's litigation release: The government's investigation of the allegations revealed that Bayer beginning in the early 1990s falsely inflated the reported drug prices referred to by the industry as the Average Wholesale Price AWP ; , the Direct Price and the Wholesale Acquisition Cost used by state and federal governments to set reimbursement rates for the federally and state funded Medicaid Program. By setting an extremely high AWP and, subsequently, selling the product to doctors at a dramatic discount, Bayer enabled physicians to receive excess reimbursement from private and government insurers. The Bayer AWPs, at issue in the investigation, involved several of Bayer's biologic products such as Kogenate, KoateHP, and Gamimmune, which are widely used in treating hemophilia and immune deficiency diseases. The investigation further revealed that Bayer was engaging in a practice referred to as "marketing the spread" that also has the effect of discouraging market competition from companies that do not inflate AWPs as a way of attracting doctors to their products. The department's probe also showed that some physicians and home health companies ignore the products of companies that refuse to create these profit windfalls for customers. 16, for instance, aciphex mg.
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[1] S. Acid, Metodos de Aprendizaje de Redes de Creencia. Aplicacion a la Clasificacion. Ph.D. Thesis. Universidad de Granada, Spain, 1999 in Spanish ; . [2] Acid S, de Campos LM. An algorithm for finding minimum d-separating sets in belief networks. In: Horvitz E, Jensen F, editors. Proceedings of the 12th Conference on Uncertainty in Artificial Intelligence. San Mateo: Morgan Kaufmann, 1996. p. 310. [3] Acid S, de Campos LM. Benedict: an algorithm for learning probabilistic belief networks. In: Proceedings of the Sixth International Conference on Information Processing and Management of Uncertainty in Knowledge Based Systems, 1996, p. 97984. [4] Acid S, de Campos LM. A hybrid methodology for learning belief networks: Benedict. Int J Approx Reason 2001; 27: 23562. [5] Acid S, de Campos LM. An algorithm for learning probabilistic belief networks using minimum dseparating sets. DECSAI Technical Report no. 01-02-22. Department of Computer Science and Artificial Intelligence, University of Granada, 2001. [6] Bouckaert RR. Belief networks construction using the minimum description length principle. In: Clarke M, Kruse R, Moral S, editors. Symbolic and Quantitative Approaches to Reasoning and Uncertainty, Lecture Notes in Computer Science 747. Berlin: Springer-Verlag, 1993. p. 418. [7] Bouckaert RR. Bayesian belief networks: from construction to inference. Ph.D. Thesis. University of Utrecht, 1995. [8] Buntine W. Theory refinement of Bayesian networks. In: Proceedings of the Seventh Conference on Uncertainty in Artificial Intelligence, 1991. p. 5260. [9] de Campos LM. Independency relationships and learning algorithms for singly connected networks. J Exp Theor Artif Intell 1998; 10: 51149. [10] de Campos LM, Huete JF. A new approach for learning belief networks using independence criteria. Int J Approx Reason 2000; 24: 1137. [11] de Campos LM, Puerta JM. Stochastic local and distributed search algorithms for learning belief networks. In: Proceedings of the III International Symposium on Adaptive Systems: Evolutionary Computation and Probabilistic Graphical Model, 2001. p. 10915. [12] Cheng J, Bell DA, Liu W. An algorithm for Bayesian belief network construction from data. In: Proceedings of AI and STAT'97, 1997. p. 8390. [13] Cheng J, Greiner R. Comparing Bayesian network classifiers. In: Laskey K, Prade H, editors. Proceedings of the 15th Conference on Uncertainty in Artificial Intelligence. San Mateo: Morgan Kaufmann, 1999. p. 1017. [14] Cooper GF, Herskovits E. A Bayesian method for the induction of probabilistic networks from data. Mach Learn 1992; 9: 30948. [15] Dash D, Druzdzel M. A hybrid anytime algorithm for the construction of causal models from sparse data. In: Laskey K, Prade H, editors. Proceedings of the 15th Conference on Uncertainty in Artificial Intelligence. San Mateo: Morgan Kaufmann, 1999. p. 1429. [16] Friedman N, Geiger D, Goldszmidt M. Bayesian network classifiers. Mach Learn 1997; 29: 13161. [17] Glymour C, Cooper G, editors. Computation, Causation and Discovery. The AAAI Press, 1999. [18] Heckerman D, Geiger D, Chickering DM. Learning Bayesian networks: the combination of knowledge and statistical data. Mach Learn 1995; 20: 197243. [19] Herskovits E, Cooper GF. Kutato: an entropy-driven system for the construction of probabilistic expert systems from databases. In: Bonissone P, editor. Proceedings of the Sixth Conference on Uncertainty in Artificial Intelligence, Cambridge, 1990. p. 5462. [20] Kullback S. Information Theory and Statistics. New York: Dover, 1968. [21] Lam W, Bacchus F. Learning Bayesian belief networks. An approach based on the MDL principle. Comput Intell 1994; 10: 26993. [22] Marshall AH, McClean SI, Shapcott CM, Hastie IR, Millard PH. Developing a Bayesian belief network for the management of geriatric hospital care. Health Care Manage Sci 2001; 4: 2530. [23] Pearl J. Probabilistic Reasoning in Intelligent Systems: Networks of Plausible Inference. San Mateo: Morgan Kaufmann, 1988 and actos.
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